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Organic compounds in which a hydrogen atom or more has been replaced by a halogen atom in an alkane molecule (saturated hydrocarbon chain). Halogen atoms include bromine, chlorine, fluorine, and iodine. Compounds may be in closed ring configurations.
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1-Phenylpropane-1,2-dione (CAS 579-07-7) is an aromatic alpha-diketone used in research chemistry and natural product studies. It is reported as a biosynthetic precursor to ephedrine alkaloids and is supplied as a high-purity reagent for laboratory and analytical applications. Intended for research use only, the material is provided with documentation to support safe handling and use.
High purity suitable for analytical and synthetic applications.
Alpha-diketone structure useful as a biosynthetic intermediate.
Available in multiple quantities and formats for flexible use.
Provided with purity documentation and a safety data sheet.
Intended for research use only; not for clinical or human use.
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CHI-KAT8i5 is a selective and orally active KAT8 inhibitor that induces cancer cell apoptosis and suppresses esophageal squamous cell carcinoma (ESCC) growth by targeting the KAT8/c-Myc signaling pathway. It is a white to off-white solid.
Selective KAT8 inhibitor
Induces cancer cell apoptosis
Suppresses ESCC tumor growth
Soluble in DMSO at 100 mg/mL
Stable as powder for up to 3 years
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Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) is an NMDA receptor modulator with glycine-site partial agonist properties. It has potential for treating major depressive disorder and is currently in phase II clinical development as an adjunctive therapy for this condition. Studies have shown that Rapastinel Trifluoroacetate produces an antidepressant-like effect and an anxiolytic effect in animal models, without altering locomotor activity.
NMDA receptor modulator with glycine-site partial agonist properties
Potential for treating major depressive disorder
Phase II clinical development as an adjunctive therapy
Produces antidepressant-like and anxiolytic effects in animal models
Does not alter locomotor activity
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CCL4 Protein Human is a small cytokine of the CC chemokine subfamily that binds to the CCR5 chemokine receptor on the cell surface promotes leukocyte aggregation under various inflammatory conditions and contributes to immune protection against human immunodeficiency virus type 1 CCL4 Protein Human is a recombinant human CCL4 (A24-N92) expressed by E coli[1]
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Sodium 2-bromoethanesulfonate is an organosulfonate reagent supplied as a 10 mM solution in DMSO for biochemical and life-science research. The compound has CAS 4263-52-9, formula C2H4BrNaO3S, and a molecular weight of 211.01 g·mol⁻¹. The solid is described as white to off-white; listed purity is 97.0% (assay 99.7%). Certificates and safety data are available.
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GluN1 (356-385) is an antigenic peptide against N-methyl-D-aspartate receptor (NMDAR) encephalitis. It reduces the density of surface NMDAR clusters in hippocampal neurons and can be used to study the pathogenesis of anti-NMDAR encephalitis.
Antigenic peptide against NMDAR encephalitis
Reduces density of surface NMDAR clusters in hippocampal neurons
Used to study pathogenesis of anti-NMDAR encephalitis
Related to peptide and derivatives, and peptide epitopes
Applicable to neurological, eye or ear disease
Associated with membrane transporter/ion channel, neuronal signaling, and iGluR pathways
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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TL13-112 is a proteolysis targeting chimera (PROTAC) designed to selectively induce degradation of anaplastic lymphoma kinase (ALK) in cellular models. It is supplied as a solid and as a 10 mM solution in DMSO for use in preclinical degradation studies, mechanistic assays, and target validation workflows.
Selective ALK degradation in cellular assays.
High purity suitable for biological studies.
Available as solid or 10 mM DMSO solution for convenient dosing.
Recommended storage conditions for powder and solvent preparations.
Applicable to mechanistic studies and preclinical target validation.
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